Prevalence of 52-kd and 60-kd Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis

Masahide Kubo, Hironobu Ihn, Yoshihide Asano, Kenichi Yamane, Norihito Yazawa, Kunihiko Tamaki

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20 Citations (Scopus)


To determine the prevalence of 52-kd and 60-kd Ro/SS-A antibodies in Japanese patients with polymyositis/dermatomyositis, we examined serum samples from 61 patients with PM/DM, 10 patients with primary Sjögren's syndrome, and 25 healthy control subjects. Six serum samples possessed anti-Ro/SS-A antibodies and were positive for anti-Ro52, anti-Ro60, or both. Two reacted with both Ro52 and Ro60, and 4 reacted with Ro52 alone. The results suggest that Ro52 is the main antigen of anti-Ro/SS-A antibodies in patients with polymyositis/dermatomyositis and that its coexistence with other defined antibodies suggests the existence of a subgroup of patients with various serologic abnormalities.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalJournal of the American Academy of Dermatology
Issue number1
Publication statusPublished - 2002 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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