Prevalence and predictive factors for clinical outcomes of isolated functional tricuspid regurgitation

Shoko Nakagawa, Hiroyuki Takahama, Keiji Hoshino, Yoshiki Yanagi, Yuki Irie, Kenji Moriuchi, Masashi Amano, Atsushi Okada, Makoto Amaki, Hideaki Kanzaki, Kengo Kusano, Teruo Noguchi, Satoshi Yasuda, Chisato Izumi

Research output: Contribution to journalArticlepeer-review


Background: A substantial number of patients have functional tricuspid regurgitation (TR). Isolated functional TR has been undertreated and may be a next target for transcatheter intervention. However, the prevalence, patient characteristics, and predictive factors for prognosis remain unclear. Methods: From patients in our echocardiographic database (N = 64,242), we extracted those with severe TR and examined prognosis according to etiologies of TR. Thereafter, we focused on two types of isolated functional TR; progressive TR after left-sided valve surgery (postoperative TR) and TR associated with annular dilatation (atrial TR). Composite adverse events were defined as all-cause death or hospitalization for heart failure (HF). Results: Of 1001 patients with severe TR (median age, 77 years; female, 58 %), 71 (7 %) patients were classified as postoperative TR, and 149 (15 %) as atrial TR. During the follow-up period (median, 1.6 years), 30 composite adverse events were observed (postoperative TR, n = 14; atrial TR, n = 16). Composite adverse events were less frequent in these two types of functional TR than TR of other etiologies. Multivariate analysis adjusted for age and sex showed that a history of hospitalization for HF, history of cardiac surgery >2 times, loop diuretics, estimated glomerular filtration rate, blood urea nitrogen, hemoglobin, platelet level, left ventricular ejection fraction, and right ventricular dimension were associated with clinical adverse events (p < 0.05), while B-type natriuretic peptide level was not. Conclusions: A considerable number of patients had isolated functional TR. Extracardiac factors such as renal function, hemoglobin and platelet are important in determining clinical outcomes.

Original languageEnglish
JournalJournal of cardiology
Publication statusAccepted/In press - 2023
Externally publishedYes


  • Anemia
  • Heart failure
  • Renal function
  • Tricuspid regurgitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Prevalence and predictive factors for clinical outcomes of isolated functional tricuspid regurgitation'. Together they form a unique fingerprint.

Cite this