Prevalence and clinical implication of metabolic syndrome in chronic heart failure - Report from MetS-CHF study

Yutaka Miura, Yoshihiro Fukumoto, Nobuyuki Shiba, Toshiro Miura, Kazunori Shimada, Yoshitaka Iwama, Atsutoshi Takagi, Hidenori Matsusaka, Takaki Tsutsumi, Akira Yamada, Shintaro Kinugawa, Masanori Asakura, Shuichi Okamatsu, Hiroyuki Tsutsui, Hiroyuki Daida, Masunori Matsuzaki, Hitonobu Tomoike, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Background: Metabolic syndrome (MetS) is a pathological condition with a clustering of metabolic components and is a well-known risk and prognostic factor for ischemic heart disease (IHD). However, the prevalence and clinical significance of MetS remain to be fully elucidated in chronic heart failure (CHF), an important clinical syndrome caused by various cardiac abnormalities. Methods and Results: The present nationwide, large-scale clinical study enrolled 3,603 patients with stage C/D CHF from 6 institutes in Japan. First, the prevalence of MetS in CHF patients was demonstrated to be 45% in males and 19% in females, which is more than double compared with the general population in Japan. The CHF patients with MetS were characterized by younger age, higher prevalence of current smoking and drinking, IHD, and hypertensive heart disease, whereas the prevalence of HF with preserved ejection fraction and MetS was higher in elderly female patients. Next, the contribution of the metabolic components (waist circumference, hypertension, glucose intolerance/diabetes mellitus and dyslipidemia) was found to be comparable between the ischemic and the non-ischemic CHF patients. Conclusions: The prevalence of MetS in CHF patients is more than double compared with the general population in Japan and suggest that the metabolic components may have a substantial effect on the development of both ischemic and non-ischemic CHF.

Original languageEnglish
Pages (from-to)2612-2621
Number of pages10
JournalCirculation Journal
Volume74
Issue number12
DOIs
Publication statusPublished - 2010

Keywords

  • Chronic heart failure
  • Metabolic syndrome
  • Obesity
  • Sex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Prevalence and clinical implication of metabolic syndrome in chronic heart failure - Report from MetS-CHF study'. Together they form a unique fingerprint.

Cite this