Pressure-driven flow control system for nanofluidic chemical process

Eiichiro Tamaki, Akihide Hibara, Haeng Boo Kim, Manabu Tokeshi, Takehiko Kitamori

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)


We developed a novel flow control system for a nanofluidic chemical process. Generally, flow control in nanochannels is difficult because of its high-pressure loss with very small volume flow rate. In our flow control method, liquid pressure in a microchannel connected to the nanochannels is regulated by utilizing a backpressure regulator. The flow control method was verified by using simple structured microchip, which included parallel nanochannels. We found that the observed flow rate was three times lower than the value expected from Hagen-Poiseuille's equation. That implied a size-dependent viscosity change in the nanochannels. Then, we demonstrated mixing of two different fluorescent solutions in a Y-shaped nanochannel and also a proton exchange reaction in the Y-shaped nanochannel. The flow control method will contribute to further integration of nanochemical systems.

Original languageEnglish
Pages (from-to)256-262
Number of pages7
JournalJournal of Chromatography A
Issue number2
Publication statusPublished - 2006 Dec 29
Externally publishedYes


  • Backpressure
  • Microchip
  • Nanochannel
  • Nanochemical process
  • Nanofluidics
  • Pressure-driven flow

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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