Pressor effect of recombinant human erythropoietin: Results of home blood pressure measurements in hemodialysis patients

Yutaka Imai, Yoshihiro Fujikura, Naoyoshi Minami, Masanori Munakata, Junichiro Hashimoto, Hiromichi Sakuma, Noriko Watanabe, Akimitsu Nishiyama, Seiichi Misawa, Hiroshi Sekino, Keishi Abe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We investigated whether the treatment of anemic hemodialysis patients with a low dose of recombinant human erythropoietin (rHEpo) for a short period would increase the blood pressure (BP). Home BP measurements were used to detect minute increases in BP. Fifty-one anemic patients on maintenance hemodialysis with a hematocrit of 25% or less received rHEpo at the dose of 4500IU/week by the intravenous route for 8 weeks. Overall, rHEpo did not increase the BP whether measured at home or in the clinic (casual BP). Hemoglobin concentration increased significantly from 7.1 ± 0.7 to 8.8 ± 0.7 g/dl. Patients were classified into two groups according to the change in mean (M) home BP induced by rHEpo: a pressor group (AMBP≥5mmHg, n=17) and a non-pressor group (AMBP<5mmHg, n = 34). The hemoglobin concentration rose significantly in both groups, but there was no change in casual BP. Home blood pressure measurements showed a gradual and continuous rise in BP in the pressor group, but not in the non-pressor group. Patients administered antihypertensive medications before rHEpo treatment accounted for 88% of the former and 50% of the latter groups. Two patients with malignant nephrosclerosis were included in the pressor group. The findings indicate that rHEpo, even given at a low dose for a short period, elevates the BP, as determined by home BP measurement, but not by casual measurements obtained in the clinic.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalThe Japanese Journal Of Nephrology
Volume36
Issue number1
DOIs
Publication statusPublished - 1994

Keywords

  • erythropoietin
  • hematocrit
  • hemodialysis
  • hemoglobin
  • home blood pressure measurement
  • hypertension

ASJC Scopus subject areas

  • Nephrology

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