Preservation of retinal morphology and functions in Royal College Surgeons rat by nilvadipine, a CA2+ antagonist

Hitoshi Yamazaki, Hiroshi Ohguro, Tadao Maeda, Ikuyo Maruyama, Yoshiko Takano, Tomomi Metoki, Mitsuru Nakazawa, Hajime Sawada, Mari Dezawa

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

Purpose. The Royal College of Surgeons (RCS) rat is the most extensively studied animal model for understanding the molecular pathology in inherited retinal degeneration, such as retinitis pigmentosa (RP). The purpose of the present study was to evaluate the pharmacologic effects of several Ca2+ antagonists on the retinal degeneration of RCS rats. Methods. Several Ca2+ antagonists, diltiazem, nicardipine, nilvadipine, and nifedipine, were intraperitoneally administered and retinal morphology and functions analyzed. Results. Among the Ca2+ antagonists, only intraperitoneally administered nilvadipine preserved retinal morphology and electroretinogram responses in RCS rats during the initial stage of retinal degeneration. Studies using immunohistochemistry, RT-PCR, and Western blot analysis revealed significant enhancement of rhodopsin kinase and αA-crystallin expression and suppression of caspase 1 and 2 expression in the retina of nilvadipine-treated rats. Conclusions. These data suggest that nilvadipine is beneficial for the preservation of photoreceptor cells in RCS rats and can be used to treat some patients with RP.

Original languageEnglish
Pages (from-to)919-926
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume43
Issue number4
Publication statusPublished - 2002 Apr 9
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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