Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice

Jun Suzuki; Takeshi Ohshima; Naohiro Yoshida; Ryuichi Kimura; Yusuke Takata; Yuji Owada; Toshimitsu Kobayashi; Yukio Katori; Noriko Osumi

doi:10.1016/j.neures.2014.02.003

Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice

Jun Suzuki, Takeshi Ohshima, Naohiro Yoshida, Ryuichi Kimura, Yusuke Takata, Yuji Owada, Toshimitsu Kobayashi, Yukio Katori, Noriko Osumi

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here, we demonstrated that the ABR thresholds of young and aged Fabp3 knockout mice were unchanged compared with those of wild-type mice. Compared with the wild-type mice, the adult mutant mice demonstrated no differences in their vulnerability to acoustic overexposure. These results suggest that Fabp3 deficiency alone does not adversely affect hearing function.

Original language	English
Pages (from-to)	64-68
Number of pages	5
Journal	Neuroscience Research
Volume	81-82
DOIs	https://doi.org/10.1016/j.neures.2014.02.003
Publication status	Published - 2014 Apr

Keywords

Acoustic overexposure
Age-related hearing loss (AHL)
Cochlea
Fatty acid-binding protein 3 (Fabp3)
H-Fabp
Noise-induced hearing loss (NIHL)

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neures.2014.02.003

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Suzuki, J., Ohshima, T., Yoshida, N., Kimura, R., Takata, Y., Owada, Y., Kobayashi, T., Katori, Y., & Osumi, N. (2014). Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice. Neuroscience Research, 81-82, 64-68. https://doi.org/10.1016/j.neures.2014.02.003

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abstract = "Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here, we demonstrated that the ABR thresholds of young and aged Fabp3 knockout mice were unchanged compared with those of wild-type mice. Compared with the wild-type mice, the adult mutant mice demonstrated no differences in their vulnerability to acoustic overexposure. These results suggest that Fabp3 deficiency alone does not adversely affect hearing function.",

keywords = "Acoustic overexposure, Age-related hearing loss (AHL), Cochlea, Fatty acid-binding protein 3 (Fabp3), H-Fabp, Noise-induced hearing loss (NIHL)",

author = "Jun Suzuki and Takeshi Ohshima and Naohiro Yoshida and Ryuichi Kimura and Yusuke Takata and Yuji Owada and Toshimitsu Kobayashi and Yukio Katori and Noriko Osumi",

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AU - Suzuki, Jun

AU - Ohshima, Takeshi

AU - Yoshida, Naohiro

AU - Kimura, Ryuichi

AU - Takata, Yusuke

AU - Owada, Yuji

AU - Kobayashi, Toshimitsu

AU - Katori, Yukio

AU - Osumi, Noriko

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