TY - JOUR
T1 - Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice
AU - Suzuki, Jun
AU - Oshima, Takeshi
AU - Yoshida, Naohiro
AU - Kimura, Ryuichi
AU - Takata, Yusuke
AU - Owada, Yuji
AU - Kobayashi, Toshimitsu
AU - Katori, Yukio
AU - Osumi, Noriko
N1 - Funding Information:
We are grateful to Drs. Yasuhiro Adachi and Yui Yamamoto for providing the Fabp3 KO mice and to Ms. Ayumi Ogasawara and Ms. Sayaka Makino for animal care. We also thank all members of the Osumi laboratory and the ENT Department for their valuable comments. The Ministry of Education, Culture, Sports, Science, and Technology (MEXT) KAKENHI supported this work (grant numbers K24659744 and K23592492 ).
PY - 2014/4
Y1 - 2014/4
N2 - Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here, we demonstrated that the ABR thresholds of young and aged Fabp3 knockout mice were unchanged compared with those of wild-type mice. Compared with the wild-type mice, the adult mutant mice demonstrated no differences in their vulnerability to acoustic overexposure. These results suggest that Fabp3 deficiency alone does not adversely affect hearing function.
AB - Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here, we demonstrated that the ABR thresholds of young and aged Fabp3 knockout mice were unchanged compared with those of wild-type mice. Compared with the wild-type mice, the adult mutant mice demonstrated no differences in their vulnerability to acoustic overexposure. These results suggest that Fabp3 deficiency alone does not adversely affect hearing function.
KW - Acoustic overexposure
KW - Age-related hearing loss (AHL)
KW - Cochlea
KW - Fatty acid-binding protein 3 (Fabp3)
KW - H-Fabp
KW - Noise-induced hearing loss (NIHL)
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U2 - 10.1016/j.neures.2014.02.003
DO - 10.1016/j.neures.2014.02.003
M3 - Article
C2 - 24560810
AN - SCOPUS:84902274230
VL - 81-82
SP - 64
EP - 68
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -