TY - JOUR
T1 - Presenilin-1 polymorphism in Alzheimer's disease and vascular dementia
AU - Matsushita, Sachio
AU - Arai, Hiroyuki
AU - Muramatsu, Taro
AU - Makimoto, Kiyoko
AU - Nakagawa, Takuma
AU - Sasaki, Hidetada
AU - Higuchi, Susumu
PY - 1997/8
Y1 - 1997/8
N2 - Recent reports suggest an association between an intronic polymorphism at the 3' position of exon 8 of the presenilin-1 (PS-1) gene and late-onset Alzheimer's disease (AD), but little is known about its role in the pathogenesis of AD. By genotyping 193 Japanese patients with vascular dementia or AD, and 186 elderly control subjects, we have shown no association between vascular dementia and this PS-1 polymorphism, though PS- 1 genotype 1/1 and allele 1 frequencies were both significantly higher among patients with AD than among controls. These results argue for a specific role of PS-1 allele 1 in the pathogenesis of AD, rather than suggesting a broader role for this allele as, for example, in vascular dementia.
AB - Recent reports suggest an association between an intronic polymorphism at the 3' position of exon 8 of the presenilin-1 (PS-1) gene and late-onset Alzheimer's disease (AD), but little is known about its role in the pathogenesis of AD. By genotyping 193 Japanese patients with vascular dementia or AD, and 186 elderly control subjects, we have shown no association between vascular dementia and this PS-1 polymorphism, though PS- 1 genotype 1/1 and allele 1 frequencies were both significantly higher among patients with AD than among controls. These results argue for a specific role of PS-1 allele 1 in the pathogenesis of AD, rather than suggesting a broader role for this allele as, for example, in vascular dementia.
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U2 - 10.1006/exnr.1997.6558
DO - 10.1006/exnr.1997.6558
M3 - Article
C2 - 9270069
AN - SCOPUS:0031213987
VL - 146
SP - 567
EP - 569
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -