Presence of neuropeptide Y in somatotrophs of cattle

Hideki Ogasawara, Hisashi Aso, Yasuhiro Nagai, Kazunori Matsumoto, Hiroaki Okamura, Sachi Tanaka, Kouichi Watanabe, Shyuichi Ohwada, Takahiro Yamaguchi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neuropeptide Y (NPY), a 36-amino acid member of the pancreatic polypeptide family, was found to be present by immunohistochemistry in the bovine adenohypophysis. NPY mRNA expression was confirmed in the adenohypophysis by RT-PCR. NPY immunoreactivity was present in about 38% of adenohypophyseal cells in the pars distalis. However, NPY immunoreactive cells (NPY-ir cells) were scarce in the zona tuberalis. Immunohistochemistry of NPY and specific hormones using mirror sections revealed that NPY was colocalized in GH immunoreactive cells. Over 90% of somatotrophs corresponded to NPY-ir cells. These results indicate that endogenous NPY is present in the bovine somatotroph and may act as an endocrine intercellular mediator in the adenohypophysis.

Original languageEnglish
Pages (from-to)274-280
Number of pages7
JournalDomestic Animal Endocrinology
Volume35
Issue number3
DOIs
Publication statusPublished - 2008 Oct 1

Keywords

  • Adenohypophysis
  • Cattle
  • Leptin
  • NPY
  • Somatotroph

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

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    Ogasawara, H., Aso, H., Nagai, Y., Matsumoto, K., Okamura, H., Tanaka, S., Watanabe, K., Ohwada, S., & Yamaguchi, T. (2008). Presence of neuropeptide Y in somatotrophs of cattle. Domestic Animal Endocrinology, 35(3), 274-280. https://doi.org/10.1016/j.domaniend.2008.06.003