Presence of multiple copies of capsulation loci in invasive Haemophilus influenzae type b (Hib) strains in Japan before introduction of the Hib conjugate vaccine

Kentaro Ueno, Junichiro Nishi, Naoko Imuta, Koichi Tokuda, Yoshifumi Kawano

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Despite the effectiveness of the Hib vaccine, multiple amplification of the capb locus contributes to vaccine failure. However, there has been no report on the effect of Hib locus amplification in Japan. We examined 24 Hib strains from Japanese children with invasive diseases due to Hib. Although all strains showed the same capb sequence, Southern blot analysis showed that four strains (16.7%) harbored multiple copies (more than two) of the capb locus. Careful analysis of the locus in circulating Hib strains is necessary now that the Hib vaccine has been introduced into Japan.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume54
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1
Externally publishedYes

Keywords

  • Capsular polysaccharide
  • Haemophilus influenzae type b
  • Hib conjugate vaccine

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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