TY - JOUR
T1 - Presence of mitogen-activated protein kinase in retinal Müller cells and its neuroprotective effect ischemia-reperfusion injury
AU - Akiyama, Hiroshi
AU - Nakazawa, Toru
AU - Shimura, Masahiko
AU - Tomita, Hiroshi
AU - Tamai, Makoto
PY - 2002/11/15
Y1 - 2002/11/15
N2 - The purpose of this study was to determine whether the mitogen-activated protein kinase (MAPK) signaling pathway in the retina plays a neuroprotective role against ischemia-reperfusion injury. Western blot analysis showed that the MAPK activity was markedly increased within an hour after ischemia-reperfusion and subsequently decreased. Immunohistochemical studies revealed that MAPK was expressed mainly in the retinal Müller cells (RMCs). Pre-ischemic intravitreal administration of a MAPK inhibitor, U0126, increased the number of ganglion cell deaths induced by ischemia-reperfusion injury. We conclude that the MAPK activated in the RMCs protects ganglion cells against the ischemia-reperfusion injury through glia-neuronal interaction.
AB - The purpose of this study was to determine whether the mitogen-activated protein kinase (MAPK) signaling pathway in the retina plays a neuroprotective role against ischemia-reperfusion injury. Western blot analysis showed that the MAPK activity was markedly increased within an hour after ischemia-reperfusion and subsequently decreased. Immunohistochemical studies revealed that MAPK was expressed mainly in the retinal Müller cells (RMCs). Pre-ischemic intravitreal administration of a MAPK inhibitor, U0126, increased the number of ganglion cell deaths induced by ischemia-reperfusion injury. We conclude that the MAPK activated in the RMCs protects ganglion cells against the ischemia-reperfusion injury through glia-neuronal interaction.
KW - Ischemia-reperfusion
KW - Neuroprotection
KW - Retinal Müller cells
KW - Retinal ganglion cell
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U2 - 10.1097/00001756-200211150-00022
DO - 10.1097/00001756-200211150-00022
M3 - Article
C2 - 12438934
AN - SCOPUS:0037113280
VL - 13
SP - 2103
EP - 2107
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 16
ER -