Presence of mitogen-activated protein kinase in retinal Müller cells and its neuroprotective effect ischemia-reperfusion injury

Hiroshi Akiyama, Toru Nakazawa, Masahiko Shimura, Hiroshi Tomita, Makoto Tamai

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The purpose of this study was to determine whether the mitogen-activated protein kinase (MAPK) signaling pathway in the retina plays a neuroprotective role against ischemia-reperfusion injury. Western blot analysis showed that the MAPK activity was markedly increased within an hour after ischemia-reperfusion and subsequently decreased. Immunohistochemical studies revealed that MAPK was expressed mainly in the retinal Müller cells (RMCs). Pre-ischemic intravitreal administration of a MAPK inhibitor, U0126, increased the number of ganglion cell deaths induced by ischemia-reperfusion injury. We conclude that the MAPK activated in the RMCs protects ganglion cells against the ischemia-reperfusion injury through glia-neuronal interaction.

Original languageEnglish
Pages (from-to)2103-2107
Number of pages5
JournalNeuroReport
Volume13
Issue number16
DOIs
Publication statusPublished - 2002 Nov 15

Keywords

  • Ischemia-reperfusion
  • Neuroprotection
  • Retinal Müller cells
  • Retinal ganglion cell

ASJC Scopus subject areas

  • Neuroscience(all)

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