Leukemic cells from nine patients with adult T-cell leukemia were examined for Fcγ and Fcμ receptors, human B-lymphocyte antigens (HBLA), and effect on PWM-induced B-cell differentiation. Fcγ receptors were detected in one and Fcμ receptors in another. Leukemic cells in both cases bore HBLA and expressed a suppressive effect on PWM-induced B-cell differentiation. However, leukemic cells from the remaining seven cases did not bear Fc receptors. In four, leukemic cells possessed HBLA and all expressed a suppressive effect on the PWM system. Some leukemic cells which did not express HBLA had the same effect on the PWM system. The origin of adult T-cell leukemia was discussed.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine