Presence of human B-lymphocyte antigens on adult T-cell leukemia cells

Toshio Hattori, Takashi Uchiyama, Kiyoshi Takatsuki, Haruto Uchino

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Leukemic cells from nine patients with adult T-cell leukemia were examined for Fcγ and Fcμ receptors, human B-lymphocyte antigens (HBLA), and effect on PWM-induced B-cell differentiation. Fcγ receptors were detected in one and Fcμ receptors in another. Leukemic cells in both cases bore HBLA and expressed a suppressive effect on PWM-induced B-cell differentiation. However, leukemic cells from the remaining seven cases did not bear Fc receptors. In four, leukemic cells possessed HBLA and all expressed a suppressive effect on the PWM system. Some leukemic cells which did not express HBLA had the same effect on the PWM system. The origin of adult T-cell leukemia was discussed.

Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalClinical Immunology and Immunopathology
Volume17
Issue number2
DOIs
Publication statusPublished - 1980 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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