Presence of human B-lymphocyte antigens on adult T-cell leukemia cells

Toshio Hattori; Takashi Uchiyama; Kiyoshi Takatsuki; Haruto Uchino

doi:10.1016/0090-1229(80)90098-7

Presence of human B-lymphocyte antigens on adult T-cell leukemia cells

Toshio Hattori, Takashi Uchiyama, Kiyoshi Takatsuki, Haruto Uchino

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Leukemic cells from nine patients with adult T-cell leukemia were examined for Fcγ and Fcμ receptors, human B-lymphocyte antigens (HBLA), and effect on PWM-induced B-cell differentiation. Fcγ receptors were detected in one and Fcμ receptors in another. Leukemic cells in both cases bore HBLA and expressed a suppressive effect on PWM-induced B-cell differentiation. However, leukemic cells from the remaining seven cases did not bear Fc receptors. In four, leukemic cells possessed HBLA and all expressed a suppressive effect on the PWM system. Some leukemic cells which did not express HBLA had the same effect on the PWM system. The origin of adult T-cell leukemia was discussed.

Original language	English
Pages (from-to)	287-295
Number of pages	9
Journal	Clinical Immunology and Immunopathology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(80)90098-7
Publication status	Published - 1980 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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