Presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid

Kazuhiro Takahashi, Masahiko Sone, Fumitoshi Satoh, Osamu Murakami, Kazuhito Totsune, Hiroaki Tanji, Nobuyuki Sato, Hisao Ito, Toraichi Mouri

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The presence of adrenomedullin-like immunoreactivity in the cerebrospinal fluid was studied by radioimmunoassay in 13 subjects with various neurological diseases. The concentrations of adrenomedullin-like immunoreactivity in the cerebrospinal fluid were 9.4 ± 3.1 pmol/l (mean ± SD, n = 13). Reverse-phase high performance liquid chromatography of the extract of the pooled cerebrospinal fluid showed that approximately 40% of the adrenomedullin-like immunoreactivity was chromatographically identical to human adrenomedullin (1-52). This is the first report that demonstrates the presence of adrenomedullin-like immunoreactivity in the human cerebrospinal fluid.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
JournalPeptides
Volume18
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Adrenomedullin
  • Cerebrospinal fluid
  • Choroid plexus
  • Chromatography
  • Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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