Preparation, structure, and in vitro chemical durability of yttrium phosphate microspheres for intra-arterial radiotherapy

Masakazu Kawashita, Naoko Matsui, Zhixia Li, Toshiki Miyazaki, Hiroyasu Kanetaka

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Chemically durable microspheres containing yttrium and/or phosphorus are useful for intra-arterial radiotherapy. In this study, we attempted to prepare yttrium phosphate (YPO 4) microspheres with high chemical durability. YPO 4 microspheres with smooth surfaces and diameters of around 25 μm were successfully obtained when gelatin droplets containing yttrium and phosphate ions were cooled and solidified in a water-in-oil emulsion and then heat-treated at 1100°C. The chemical durability of the heat-treated microspheres in a simulated body fluid at pH = 6 and 7 was high enough for clinical application of intra-arterial radiotherapy.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume99 B
Issue number1
DOIs
Publication statusPublished - 2011 Oct

Keywords

  • chemical durability
  • intra-arterial radiotherapy
  • microspheres
  • yttrium phosphate

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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