Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties

Toshiharu Takahashai, Masanobu Kamitakahara, Giichiro Kawachi, Koji Ioku

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4) 6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
Publication statusPublished - 2008 Jan 1

Keywords

  • Adsorption properties
  • Granules
  • Hydroxyapatite

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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