Preparation of porous yttrium oxide microparticles by gelation of ammonium alginate in aqueous solution containing yttrium ions

Masakazu Kawashita, Naoko Matsui, Zhixia Li, Toshiki Miyazaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Porous Y2O3 microparticles 500 μm in size were obtained, when 1 wt%-ammonium alginate aqueous solution was dropped into 0.5 M-YCl3 aqueous solution by a Pasteur pipette and the resultant gel microparticles were heat-treated at 1100°C. Small pores less than 1 μm were formed in the microparticles by the heat treatment. The bulk density of the heat-treated microparticle was as low as 0.66 g cm-3. The chemical durability of the heat-treated microparticles in simulated body fluid at pH = 6 and 7 was high enough for clinical application of in situ radiotherapy. Although the size of the microparticles should be decreased to around 25 μm using atomizing device such as spray gun for clinical application, we found that the porous Y2O3 microparticles with high chemical durability and low density can be obtained by utilizing gelation of ammonium alginate in YCl3 aqueous solution in this study.

Original languageEnglish
Pages (from-to)1837-1843
Number of pages7
JournalJournal of Materials Science: Materials in Medicine
Volume21
Issue number6
DOIs
Publication statusPublished - 2010 Jun

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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