Preparation of magnetic iron oxide nanoparticles for hyperthermia of cancer in a FeCl2-NaNO3-NaOH aqueous system

Zhixia Li, Masakazu Kawashita, Norio Araki, Michihide Mitsumori, Masahiro Hiraoka, Masaaki Doi

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28 Citations (Scopus)


Magnetic iron oxide nanoparticles (MIONPs) were synthesized in a FeCl 2-NaNO3-NaOH aqueous system under various initial Fe 2+/NO-3 molar ratios (α) and Fe 2+/OH- molar ratios (β) in order to clarify the effects of the initial molar ratio of reactants on the reaction mechanism. The Fe2+/NO-3 /OH- molar ratio of 3 : 1 : 5 led to the formation of magnetic nanoparticles mainly composed of magnetite (Fe3O4) and maghemite (γ-Fe2O 3). The 36 nm sized γ-Fe2O3 and 413 nm sized Fe3O4 were obtained by changing the order in which NaNO3 was added to a NaOH solution. The in vitro heat generations of the resulting MIONPs in an agar phantom were measured under an alternating magnetic field (100 kHz, 23.9 kA/m). The temperature rise (δT) of the agar phantom for the 36 nm sized γFe2O3 was 55°C in the first 140 s, with a concentration of 58 mg Fe/mL. Our results showed that it is possible to prepare MIONPs with high heating efficiencies under optimal conditions using the present method.

Original languageEnglish
Pages (from-to)643-661
Number of pages19
JournalJournal of Biomaterials Applications
Issue number7
Publication statusPublished - 2011 Mar


  • heating efficiency
  • hyperthermia of cancer.
  • initial molecular ratio of reactant
  • magnetic iron oxide nanoparticles
  • oxidation-precipitation

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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