Preparation of layer-by-layer films composed of polysaccharides and poly(amidoamine) dendrimer bearing phenylboronic acid and their pH- and sugar-dependent stability

Kentaro Yoshida, Keisuke Suwa, Jun Ichi Anzai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Layer-by-layer films composed of polysaccharides and poly(amidoamine) dendrimer bearing phenylboronic acid (PBA-PAMAM) were prepared to study the deposition behavior of the films and their stability in buffer solutions and in sugar solutions. Alginic acid (AGA) and carboxymethylcellulose (CMC) were employed as counter-polymers in constructing LbL films. AGA/PBA-PAMAM films were successfully prepared at pH 6.0-9.0, whereas the preparation of CMC/PBA-PAMAM film was unsuccessful at pH 8.0 and 9.0. The results show that the LbL films formed mainly through electrostatic affinity between PBA-PAMAM and polysaccharides, while, for AGA/PBA-PAMAM films, the participation of boronate ester bonds in the films was suggested. AGA/PBA-PAMAM films were stable in the solutions of pH 6.0-9.0. In contrast, CMC/PBA-PAMAM films decomposed at pH 7.5-9.0. The AGA/PBA-PAMAM films decomposed in response to 5-30 mM fructose at pH 7.5, while the films were stable in glucose solutions. Thus, AGA is useful as a counter-polymer for constructing PBA-PAMAM films that are stable at physiological pH and decompose in response to fructose.

Original languageEnglish
Article number425
JournalMaterials
Volume9
Issue number6
DOIs
Publication statusPublished - 2016 May 28

Keywords

  • Alginic acid
  • Carboxymethylcellulose
  • Dendrimer
  • Layer-by-layer film
  • PH-sensitive
  • Phenylboronic acid
  • Polysaccharide
  • Sugar-sensitive

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Preparation of layer-by-layer films composed of polysaccharides and poly(amidoamine) dendrimer bearing phenylboronic acid and their pH- and sugar-dependent stability'. Together they form a unique fingerprint.

  • Cite this