Abstract
The sugar sensitive microcapsules were prepared by a layer-by-layer deposition of concanavalin A (Con A) and glycogen on a calcium carbonate particle containing fluorescein-labeled insulin (F-insulin). The Con Alglycogen multilayer capsules were formed through sugar-lectin interactions by using inner and outer poly(ethyleneimine)/poly(vinyl sulfate) multilayers as supports, while without the supports the microcapsules could not be formed. Fluorescent microscope observations revealed that the capsules thus prepared are spherical in shape with 3-10 m diameter. The microcapsules released encapsulated F-insulin upon addition of sugars. This is because the added sugars replace glycogen in the binding site of Con A, resulting in the enhanced permeability of the microcapsules to insulin.
Original language | English |
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Pages (from-to) | 386-390 |
Number of pages | 5 |
Journal | Journal of Nanoscience and Nanotechnology |
Volume | 9 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 Jan |
Externally published | Yes |
Keywords
- Concanavalin a
- Glycogen
- Insulin
- Multilayer microcapsule
- Sugar-sensitive microcapsule
ASJC Scopus subject areas
- Bioengineering
- Chemistry(all)
- Biomedical Engineering
- Materials Science(all)
- Condensed Matter Physics