Preparation of hybrid-type vascular prosthesis using phospholipid polymer surfaces with cell substitution function

Kayahiko Makita, Ryuzea Miura, Sang Mo Ye, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to conferencePaperpeer-review

Abstract

The purpose of the research is preparation of a new-type hybrid artificial blood vessel with small inner diameter less than 4mm. We paid attention 10 the mechanical property and blood compatibility of the material for preparing the artificial blood vessel. As a core material, segmented polyurethane was used. The inner surface of the artificial blood vessel should have an excellent antithrombogenicity at early stage after implantation and it goes adhesiveness of human umbilical endothelial cells. Thus, the surface should be covered with a blood compatible phospholipid polymer, that is, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. The appearance where smooth muscle cells invade on the substrate coated with MPC polymer was observed.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • Hollow fiber
  • Human umbilical endothelial cell
  • Phospholipid polymer
  • Segmented polyurethane
  • Smooth muscle cell

ASJC Scopus subject areas

  • Engineering(all)

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