Preparation of H2O2-induced poly (amidoamine) dendrimer-release multilayer films

Katsuhiko Sato, Kazuma Awaji, Megumi Ito, Jun ichi Anzai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Poly (amidoamine) (PAMAM) dendrimer-release multilayer films were prepared using phenylboronic acid-modified PAMAM dendrimers (PBA-D) and poly (vinyl alcohol) (PVA) through boronate ester bonds. The (PBA-D/PVA)10 film was stable in pH 9.0 solution. Upon addition of H2O2, PAMAM dendrimers were released from the (PBA-D/PVA)10 film due to oxidative scission of the carbon-boron bond in the PBA residues in PBA-D. For example, 75 and 90% of the PBA-D was released from the (PBA-D/PVA)10 film within 30 min of exposure to 0.5 and 1 mM H2O2, respectively. In addition, (PBA-D/PVA)10 films containing glucose oxidase responded to the presence of 1 mM glucose in pH 7.4 solution due to the enzymatic production of H2O2.

Original languageEnglish
Pages (from-to)877-882
Number of pages6
JournalColloid and Polymer Science
Issue number5
Publication statusPublished - 2017 May 1


  • Dendrimer
  • Drug delivery system
  • Glucose response
  • Hydrogen peroxide
  • LbL film
  • Phenylboronic acid

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry


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