Preparation of hollow y2O3 microspheres for in Situ radiotherapy of cancer by enzymatic reaction

Masakazu Kawashita, Yoshihisa Takayama, Tadashi Kokubo, Gikan H. Takaoka, Norio Araki, Masahiro Hiraoka

Research output: Contribution to journalArticlepeer-review


Chemically durable microspheres 20-30 μm in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer as they can be activated by neutron bombardment to become β-emitters and can be injected in the vicinity of the cancer to provide a large localized dose of β-radiation. In this study, preparation of hollow Y2O 3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y2O3 microspheres 20-30 μm in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, whereas the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y 2O3 microspheres showed high chemical durability.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalKey Engineering Materials
Volume309-311 I
Publication statusPublished - 2006 Jan 1


  • Cancer
  • Enzymatic reaction
  • Hollow microsphere
  • Radiotherapy
  • Yttrium

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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