Preparation of blood compatible nanoparticles bearing phosphorylcholine group

Kazuhiko Ishihara; Tomohiro Konno; Kimio Kurita; Yasuhiko Iwasaki; Nobuo Nakabayashi

Preparation of blood compatible nanoparticles bearing phosphorylcholine group

Kazuhiko Ishihara, Tomohiro Konno, Kimio Kurita, Yasuhiko Iwasaki, Nobuo Nakabayashi

Research output: Contribution to journal › Conference article › peer-review

Abstract

Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.

Original language	English
Pages (from-to)	283-284
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	40
Issue number	1
Publication status	Published - 1999 Mar 1
Externally published	Yes
Event	Proceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA Duration: 1999 Mar 21 → 1999 Mar 25

ASJC Scopus subject areas

Polymers and Plastics

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Preparation of blood compatible nanoparticles bearing phosphorylcholine group. / Ishihara, Kazuhiko; Konno, Tomohiro; Kurita, Kimio; Iwasaki, Yasuhiko; Nakabayashi, Nobuo.

In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 40, No. 1, 01.03.1999, p. 283-284.

Research output: Contribution to journal › Conference article › peer-review

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abstract = "Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.",

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T1 - Preparation of blood compatible nanoparticles bearing phosphorylcholine group

AU - Ishihara, Kazuhiko

AU - Konno, Tomohiro

AU - Kurita, Kimio

AU - Iwasaki, Yasuhiko

AU - Nakabayashi, Nobuo

PY - 1999/3/1

Y1 - 1999/3/1

N2 - Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.

AB - Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.

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M3 - Conference article

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VL - 40

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EP - 284

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

SN - 0032-3934

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T2 - Proceedings of the 1999 ACS Anaheim Meeting

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