Abstract
Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.
Original language | English |
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Pages (from-to) | 283-284 |
Number of pages | 2 |
Journal | American Chemical Society, Polymer Preprints, Division of Polymer Chemistry |
Volume | 40 |
Issue number | 1 |
Publication status | Published - 1999 Mar 1 |
Externally published | Yes |
Event | Proceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA Duration: 1999 Mar 21 → 1999 Mar 25 |
ASJC Scopus subject areas
- Polymers and Plastics