Preparation of a fine powder of 2-deoxy-2-[18F]fluoro-D-glucose suitable for inhalation to diagnose lung diseases by means of PET

Fumiyoshi Ojima, Tatsuo Ido, Toshihiro Takahashi, Jun Hatazawa, Masatoshi Ito, Hidetada Sasaki, Masaru Yanai, Takashi Aikawa, Tamotsu Takishima, Kenji Abiko, Masafumi Amano

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Fine 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) powder was obtained by adding diethyl ether into a methyl alcohol solution of18FDG and other sugar as seed. When micronized particles of sodium N-acetyl-neuraminate (Neu5Ac-Na) were used as seed crystals, particles containing18FDG were obtained and 80% of them were smaller than 10μm in size. More than 60 % of these crystals were 4-6 μm in size. In a preclinical study of forced inhalation in a dog, the18FDG fine powder was mainly distributed in the trachea. The radioactivity in the trachea then increased once and a gradual decrease followed. The radioactivity was transferred into the blood and radioactivity incorporation into the heart was observed. After a normal volunteer inhaled18FDG dry powder aerosol, the radioactivity was found in the respiratory tract and the peripheral area of the lung by means of PET. Absorption and in vivo dynamics of the18FDG were also analysed.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalAnnals of Nuclear Medicine
Volume3
Issue number3
DOIs
Publication statusPublished - 1989 Dec

Keywords

  • FDG dry powder aerosol
  • Mucociliary clearance
  • PET study

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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