Preparation of 2-iodo-1,3-butadienes from 1-trimethylsilyl-2,3- butadienes and their functionalizations

Takashi Nishiyama, Tomoyuki Esumi, Yoshiharu Iwabuchi, Hiroshi Irie, Susumi Hatakeyama

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Successive treatment of 1-trimethylsilyl-2.3-butadienes with iodine and tetra-n-butylammonium fluoride in the same flask affords 2-iodo-1.3- butadienes in good yields and their palladium-catalyzed carbonylation and alkynylation allows introduction of ester and alkynyl groups to the 2- position bearing an iodine atom leading to various 2.3-disubstituted 1,3- butadienes.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number1-2
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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