Preparation of 1,4-bis(2-ethynyl-3-thienyl)benzenes as versatile spacers for connection of heterocycles

Kozo Toyota, Yoichi Goto, Kazuyuki Okada, Noboru Morita

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Iodination of 1,4-di(3-thienyl)benzene gave 1,4-bis(2-iodo-3-thienyi)-benzene, which was converted to 1,4-bis(2-ethynyl-3-thienyl)benzene. Novel 1,4-bis|2-(pyridylethynyl)-3-thienyl)benzene ligands containing the bis(ethynylthienyl)benzene spacer were prepared by Sonogashira reaction. Advantage of the spacer was demonstrated by introducing functionalized alkyl groups to the 5-position of the thiophene ring of 1,4-bis|2-(trialkylsilylethynyl)-3-thienyl|benzene.

Original languageEnglish
Pages (from-to)2227-2236
Number of pages10
JournalHeterocycles
Volume71
Issue number10
DOIs
Publication statusPublished - 2007 Oct 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Preparation of 1,4-bis(2-ethynyl-3-thienyl)benzenes as versatile spacers for connection of heterocycles'. Together they form a unique fingerprint.

Cite this