Preparation for highly sensitive MRI contrast agents using core/shell type nanoparticles consisting of multiple SPIO cores with thin silica coating

Kazuo Tanaka, Asako Narita, Narufumi Kitamura, Wataru Uchiyama, Masahito Morita, Toshiro Inubushi, Yoshiki Chujo

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

We describe here the facile and robust preparation methods for the multiple-SPIO-containing silica-coated core/shell type nanoparticles which can serve as a highly sensitive MRI contrast agent. The imidazolium-tethered core/shell type particles were synthesized, and the centrifugal selection for the multiple-SPIO-containing particles and the etching process to fabricate thin silica layers were carried out to improve the proton relaxivity of water tissue. We found that the synthetic particles can provide ∼7-fold clearer contrasts than that of the particles before treatments. In addition, the particles can show good dispersibility at least for 1 week in aqueous media.

Original languageEnglish
Pages (from-to)11759-11762
Number of pages4
JournalLangmuir
Volume26
Issue number14
DOIs
Publication statusPublished - 2010 Jul 20
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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