Preparation and photo-induced activities of water-soluble amyloid β-C60 complexes

Naoki Hasunuma, Masahiro Kawakami, Hirotsugu Hiramatsu, Takakazu Nakabayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have shown that fullerene (C60) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril structures are considered to be associated with Alzheimer's disease. The water-solubility of fullerene arises from the generation of a nanosized complex between fullerene and the monomer species of Aβ40 (Aβ40-C60). The prepared Aβ40-C60 exhibits photo-induced activity with visible light to induce the inhibition of Aβ40 fibrillation and the cytotoxicity for cultured HeLa cells. The observed photo-induced phenomena result from the generation of singlet oxygen via photoexcitation, inducing oxidative damage to Aβ40 and HeLa cells. The oxidized Aβ40 following photoexcitation of Aβ40-C60 was confirmed by mass spectrometry.

Original languageEnglish
Pages (from-to)17847-17853
Number of pages7
JournalRSC Advances
Volume8
Issue number32
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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