Preparation and in vitro apatite-forming ability of porous and non-porous titania microspheres

Zhixia Li, Toshiki Miyazaki, Masakazu Kawashita

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Porous and non-porous titania microspheres with the anatase or rutile phase were successively prepared by the sol-gel process followed by heat treatment at various temperatures. The pore size of the prepared microspheres was effectively controlled by incorporating silica nanoparticles of different diameters. The apatite-forming ability of the microspheres was investigated in a simulated body fluid, with ion concentrations nearly equal to those of human blood plasma. Results indicated that the titania microspheres with either anatase or rutile structure induced the formation of calcium phosphate compounds (CaPs) on the microsphere surface. The deposition of CaPs was more pronounced on the TiO2 microspheres calcined at 600°C (anatase structure) and 800°C (rutile structure), compared to that calcined at 500°C (anatase structure). Additionally, anatase micro-spheres with smooth surface and low specific surface area favored the formation of CaPs, compared to porous microspheres. This indicates that nanoscale pores do not essentially favor apatite formation.

Original languageEnglish
Pages (from-to)782-787
Number of pages6
JournalNippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
Issue number1417
Publication statusPublished - 2013 Sep


  • Anatase
  • Apatite
  • Calcium phosphate compounds
  • Rutile
  • Titania microspheres

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry


Dive into the research topics of 'Preparation and in vitro apatite-forming ability of porous and non-porous titania microspheres'. Together they form a unique fingerprint.

Cite this