Preoperative bronchoscopic cancer confirmation does not increase risk of recurrence in stage 1A non-small cell lung cancer

Jiro Abe, Toshimasa Okazaki, Naohiko Kikuchi, Satomi Takahashi, Akira Sakurada, Yoshinori Okada

Research output: Contribution to journalArticlepeer-review

Abstract

Objective This study was conducted to evaluate the risk of recurrence possibly caused by preoperative bronchoscopic cancer confirmation in stage1A non-small cell lung cancer. Methods One hundred and seventy-nine cases of peripheral non-small cell lung cancer (including 151 adenocarcinoma) with no more than 3 cm in their tumor longer diameter were selected. All patients underwent preoperative diagnostic bron-choscopy followed by lobectomy, and were demonstrated to have pathologically free of lymph node involvement and pleural involvement. Radiological and pathological low-grade adenocarcinomas were excluded. Of 179 cases, 95 were confirmed lung cancer by bronchoscope (Group 1) and rest 84 had failed cancer confirmation by bronchoscope before surgery (Group 2). Forty-eight pairs for non-small cell lung cancer and 41 pairs for adenocarcinoma were identified from each group by propensity caliper matching. Kaplan–Meier method and log-rank test were performed on matched groups, and Cox proportional hazard model analysis was performed on whole matched cases. Results Log-rank test revealed no significant inferiority of recurrence-free survival of Group 1 in both all-NSCLC and adenocarcinoma subset. Cox proportional hazard model analysis also revealed that the ‘presence of preoperative bronchoscopic cancer confirmation’ dose not increase risk of recurrence in both NSCLC and adenocarcinoma subset. Conclusions It is unlikely that preoperative bronchoscopic cancer confirmation would increase recurrence risk in stage1A non-small cell lung cancer; however, a future prospective study with larger cohorts would be warranted to validate the results.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalGeneral thoracic and cardiovascular surgery
Volume66
Issue number5
DOIs
Publication statusPublished - 2018 Mar 21

Keywords

  • Bronchoscope
  • Diagnosis
  • Lung adenocarcinoma
  • Prognostic factor

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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