TY - JOUR
T1 - Prenatal programming of stress responsiveness and behaviours
T2 - Progress and perspectives
AU - Hamada, Hirotaka
AU - Matthews, Stephen G.
N1 - Funding Information:
The authors work cited herein was supported by the Canadian Institutes of Health Research (FDN‐148368) and the Natural Sciences and Engineering Research Council.
Funding Information:
Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research, Grant/Award Number: FDN‐148368
Publisher Copyright:
© 2018 British Society for Neuroendocrinology
PY - 2019/3
Y1 - 2019/3
N2 - Parental exposure to stress or glucocorticoids either before or during pregnancy can have profound influences on neurodevelopment, neuroendocrine function and behaviours in offspring. Specific outcomes are dependent on the nature, intensity and timing of the exposure, as well as species, sex and age of the subject. Most recently, it has become evident that outcomes are not confined to first-generation offspring and that there may be intergenerational and transgenerational transmission of effects. There has been intense focus on the mechanisms by which such early exposure leads to long-term and potential transgenerational outcomes, and there is strong emerging evidence that epigenetic processes (histone modifications, DNA methylation, and small non-coding RNAs) are involved. New knowledge in this area may allow the development of interventions that can prevent, ameliorate or reverse the long-term negative outcomes associated with exposure to early adversity. This review will focus on the latest research, bridging human and pre-clinical studies, and will highlight some of the limitations, challenges and gaps that exist in the field.
AB - Parental exposure to stress or glucocorticoids either before or during pregnancy can have profound influences on neurodevelopment, neuroendocrine function and behaviours in offspring. Specific outcomes are dependent on the nature, intensity and timing of the exposure, as well as species, sex and age of the subject. Most recently, it has become evident that outcomes are not confined to first-generation offspring and that there may be intergenerational and transgenerational transmission of effects. There has been intense focus on the mechanisms by which such early exposure leads to long-term and potential transgenerational outcomes, and there is strong emerging evidence that epigenetic processes (histone modifications, DNA methylation, and small non-coding RNAs) are involved. New knowledge in this area may allow the development of interventions that can prevent, ameliorate or reverse the long-term negative outcomes associated with exposure to early adversity. This review will focus on the latest research, bridging human and pre-clinical studies, and will highlight some of the limitations, challenges and gaps that exist in the field.
KW - HPA axis
KW - behaviour
KW - foetus
KW - glucocorticoids
KW - programming
KW - stress
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U2 - 10.1111/jne.12674
DO - 10.1111/jne.12674
M3 - Review article
C2 - 30582647
AN - SCOPUS:85060935886
VL - 31
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
SN - 0953-8194
IS - 3
M1 - e12674
ER -