Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS

Toshio Hattori, Shojiro Ikematsu, Atsushi Koito, Shuzo Matsushita, Yosuke Maeda, Masao Hada, Michio Fujimaki, Kiyoshi Takatsuki

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91 Citations (Scopus)

Abstract

Glycyrrhizin (GL) at a dose of 400-1600 mg/day (7.2-30.8 mg/kg/day) was administered intravenously for a period of more than a month, on 6 separate occasions, to 3 hemophiliacs with acquired immune deficiency syndrome (AIDS). Human immunodeficiency virus type 1 (HIV-1) p24 antigen was detected at the beginning of 5 of the 6 treatment courses. Viral antigen was not detected at the end of or during 3 of the 5 treatment courses and decreased to a low level following the 2 other courses. These findings suggest that GL might inhibit HIV-1 replication in vivo.

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalAntiviral Research
Volume11
Issue number5-6
DOIs
Publication statusPublished - 1989 Jan 1
Externally publishedYes

Keywords

  • AIDS
  • Antigen, p24
  • Glycyrrhizin
  • HIV-1

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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    Hattori, T., Ikematsu, S., Koito, A., Matsushita, S., Maeda, Y., Hada, M., Fujimaki, M., & Takatsuki, K. (1989). Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS. Antiviral Research, 11(5-6), 255-261. https://doi.org/10.1016/0166-3542(89)90035-1