Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery

Hiroaki Kazui, Etsuro Mori, Shingo Ohkawa, Takaharu Okada, Takeo Kondo, Ryuji Sakakibara, Osamu Ueki, Yoshiyuki Nishio, Kazunari Ishii, Tetsuro Kawaguchi, Masatsune Ishikawa, Masatoshi Takeda

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We identified factors that predict the disappearance of the triad of symptoms (gait disturbance, cognitive impairment and urinary incontinence) of idiopathic normal pressure hydrocephalus (iNPH) following shunt surgery in this study. We classified 71 patients with iNPH into those whose objective symptoms disappeared (disappearance group) or remained (residual group), for each of the triad symptoms 12 months after shunt surgery. Logistic regression analyses were used to identify the predictors of the disappearance of symptoms among 10 variables before shunt surgery (e.g., age, sex, severity of symptoms, Evans index, cerebrospinal fluid (CSF) pressure, CSF stasis on computerized tomographic cisternography, regional cerebral blood flow on single photon emission computed tomography, three kinds of prior diseases). For each of the triad symptoms, mild symptoms before shunt surgery were predictors of the disappearance of the symptom. Young age was also a predictor of the disappearance of gait disturbance. When the analysis was conducted using subscores of the Mini Mental State Examination, a successful visuoconstruction subtest and an absence of hypertension were predictors of the disappearance of cognitive impairment. None of the neuroimaging examinations predicted the disappearance of symptoms after shunt surgery in this study.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalJournal of the neurological sciences
Volume328
Issue number1-2
DOIs
Publication statusPublished - 2013 May 15

Keywords

  • Disappearance of clinical symptoms
  • Idiopathic normal pressure hydrocephalus
  • Neuroimaging examination
  • Predictors
  • Risk factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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