TY - JOUR
T1 - Predictive markers for late cervical lymph node metastasis in patients with NO squamous cell carcinoma of the tongue
AU - Kurokawa, Hideo
AU - Yamashita, Yoshihiro
AU - Matsumoto, Shinobu
AU - Takamori, Koichi
AU - Igawa, Kaori
AU - Kashima, Koji
AU - Zhang, Min
AU - Fukuyama, Hiroshi
AU - Takahashi, Tetsu
AU - Sakoda, Sumio
PY - 2006/6
Y1 - 2006/6
N2 - Objective: To find useful markers for predicting late cervical metastasis in patients with NO squamous cell carcinoma of the tongue. Patients and Methods: The clinicopathological features of 57 consecutive patients with previously untreated NO squamous cell carcinoma of the tongue were reviewed. Thirty patients had Tl disease, 20 had T2 disease, and 7 had T3 disease. All patients were treated with partial glossectomy without elective neck dissection. Clinicopathological factors were analysed to determine the factors predicting late cervical lymph node metastasis. Results: The overall cervical lymph node metastasis rate was 19.3%. The clinicopathologic factors significantly associated with the development of cervical lymph node metastasis were tumour size (30 mm), tumour depth (4 mm), differentiation (moderate), mode of invasion (G4C, 4D), microvascular invasion (present), muscle invasion (present), and invasive front grading (12 points). In a multivariate logistic regression analysis, invasive front grading ≥12 points in squamous cell carcinoma of the tongue with a tumour depth ≥4 mm had predictive value for late cervical lymph node metastasis. Conclusions: The results indicate that patients with NO invasive tongue carcinoma with a tumour depth ≥4 mm or invasive front grading ≥12 points should be considered at high risk for late cervical lymph node metastasis. These factors should be considered in the decision to electively treat the neck.
AB - Objective: To find useful markers for predicting late cervical metastasis in patients with NO squamous cell carcinoma of the tongue. Patients and Methods: The clinicopathological features of 57 consecutive patients with previously untreated NO squamous cell carcinoma of the tongue were reviewed. Thirty patients had Tl disease, 20 had T2 disease, and 7 had T3 disease. All patients were treated with partial glossectomy without elective neck dissection. Clinicopathological factors were analysed to determine the factors predicting late cervical lymph node metastasis. Results: The overall cervical lymph node metastasis rate was 19.3%. The clinicopathologic factors significantly associated with the development of cervical lymph node metastasis were tumour size (30 mm), tumour depth (4 mm), differentiation (moderate), mode of invasion (G4C, 4D), microvascular invasion (present), muscle invasion (present), and invasive front grading (12 points). In a multivariate logistic regression analysis, invasive front grading ≥12 points in squamous cell carcinoma of the tongue with a tumour depth ≥4 mm had predictive value for late cervical lymph node metastasis. Conclusions: The results indicate that patients with NO invasive tongue carcinoma with a tumour depth ≥4 mm or invasive front grading ≥12 points should be considered at high risk for late cervical lymph node metastasis. These factors should be considered in the decision to electively treat the neck.
KW - Carcinoma
KW - Lymphatic metastasis
KW - Neoplasm invasiveness
KW - Squamous cell
KW - Tongue neoplasms
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U2 - 10.1016/S0915-6992(06)80006-3
DO - 10.1016/S0915-6992(06)80006-3
M3 - Article
AN - SCOPUS:78650586176
VL - 18
SP - 120
EP - 126
JO - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
JF - Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
SN - 2212-5558
IS - 2
ER -