Predictive markers for late cervical lymph node metastasis in patients with NO squamous cell carcinoma of the tongue

Hideo Kurokawa, Yoshihiro Yamashita, Shinobu Matsumoto, Koichi Takamori, Kaori Igawa, Koji Kashima, Min Zhang, Hiroshi Fukuyama, Tetsu Takahashi, Sumio Sakoda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To find useful markers for predicting late cervical metastasis in patients with NO squamous cell carcinoma of the tongue. Patients and Methods: The clinicopathological features of 57 consecutive patients with previously untreated NO squamous cell carcinoma of the tongue were reviewed. Thirty patients had Tl disease, 20 had T2 disease, and 7 had T3 disease. All patients were treated with partial glossectomy without elective neck dissection. Clinicopathological factors were analysed to determine the factors predicting late cervical lymph node metastasis. Results: The overall cervical lymph node metastasis rate was 19.3%. The clinicopathologic factors significantly associated with the development of cervical lymph node metastasis were tumour size (30 mm), tumour depth (4 mm), differentiation (moderate), mode of invasion (G4C, 4D), microvascular invasion (present), muscle invasion (present), and invasive front grading (12 points). In a multivariate logistic regression analysis, invasive front grading ≥12 points in squamous cell carcinoma of the tongue with a tumour depth ≥4 mm had predictive value for late cervical lymph node metastasis. Conclusions: The results indicate that patients with NO invasive tongue carcinoma with a tumour depth ≥4 mm or invasive front grading ≥12 points should be considered at high risk for late cervical lymph node metastasis. These factors should be considered in the decision to electively treat the neck.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalAsian Journal of Oral and Maxillofacial Surgery
Volume18
Issue number2
DOIs
Publication statusPublished - 2006 Jun
Externally publishedYes

Keywords

  • Carcinoma
  • Lymphatic metastasis
  • Neoplasm invasiveness
  • Squamous cell
  • Tongue neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Orthopedics and Sports Medicine

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