TY - JOUR
T1 - Prediction of sensitivity to 1-β-d-arabinofuranosylcytosine by the plateau level of its 5′-triphosphate in human lymphoblastic cell lines in vitro
AU - Abe, Ikuo
AU - Saito, Sachiko
AU - Hori, Katsuyoshi
AU - Suzuki, Maroh
AU - Sato, Haruo
PY - 1983/7
Y1 - 1983/7
N2 - Parameters for metabolism of 1-β-d-arabinofuranosylcytosine (ara-C) were examined to know whether the prediction of ara-C sensitivity is possible or not using 9 human lymphoblastic cell lines, 3 T cell lines and 6 B cell lines in vitro. Neither the capacity for synthesis, degradation, of 1-β-d-arabinofuranosylcytosine 5′-triphosphate (ara-CTP), generally lower in the T than B cell lines, nor deamination of ara-C, negligible in the B cell lines, could be correlated to the drug sensitivity. On the other hand, significant correlation was obtained between the sensitivity and the plateau level of ara-CTP. We consider that ara-C sensitivity could be predicted by measuring the plateau ara-CTP level before commencement of chemotherapy.
AB - Parameters for metabolism of 1-β-d-arabinofuranosylcytosine (ara-C) were examined to know whether the prediction of ara-C sensitivity is possible or not using 9 human lymphoblastic cell lines, 3 T cell lines and 6 B cell lines in vitro. Neither the capacity for synthesis, degradation, of 1-β-d-arabinofuranosylcytosine 5′-triphosphate (ara-CTP), generally lower in the T than B cell lines, nor deamination of ara-C, negligible in the B cell lines, could be correlated to the drug sensitivity. On the other hand, significant correlation was obtained between the sensitivity and the plateau level of ara-CTP. We consider that ara-C sensitivity could be predicted by measuring the plateau ara-CTP level before commencement of chemotherapy.
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U2 - 10.1016/0277-5379(83)90062-7
DO - 10.1016/0277-5379(83)90062-7
M3 - Article
C2 - 6576907
AN - SCOPUS:0020507917
VL - 19
SP - 941
EP - 944
JO - European Journal of Cancer and Clinical Oncology
JF - European Journal of Cancer and Clinical Oncology
SN - 0277-5379
IS - 7
ER -