Prediction of respiratory distress syndrome by the level of pulmonary surfactant protein A in cord blood sera

Kazutoshi Cho; Tadashi Matsuda; Satoru Okajima; Yoshinori Matsumoto; Tadashi Sagawa; Seiichiro Fujimoto; Kunihiko Kobayashi

Prediction of respiratory distress syndrome by the level of pulmonary surfactant protein A in cord blood sera

Kazutoshi Cho, Tadashi Matsuda, Satoru Okajima, Yoshinori Matsumoto, Tadashi Sagawa, Seiichiro Fujimoto, Kunihiko Kobayashi

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Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The purpose of this study was to determine the utility of measuring the level of pulmonary surfactant protein A (SP-A) in cord blood sera to predict for respiratory distress syndrome (RDS). SP-A levels in cord blood sera from 48 infants born at gestational ages < 32 weeks were measured by a sandwich ELISA system. Mean value of SP-A in cord blood was 5.8 ng/ml in cases with RDS and 15.1 ng/ml in those without RDS (p = 0.002). The best cut-off point of cord blood SP-A to predict RDS was determined as 10 ng/ml. The sensitivity and the specificity of the cut-off point for predicting RDS were 81 and 76%, respectively. Multivariate regression analysis showed that high SP-A level in cord blood, premature rupture of the membranes longer than 24 h and heavy birth weight were all significantly related to the non-RDS outcome. Copyright (C) 2000 S. Karger AG, Basel.

Original language	English
Pages (from-to)	83-87
Number of pages	5
Journal	Biology of the Neonate
Volume	77
Issue number	2
Publication status	Published - 2000 Feb 1

Keywords

Cord blood sera
Diagnosis
Lung maturation
Prediction
Premature infant
Pulmonary surfactant protein A
Respiratory distress syndrome

ASJC Scopus subject areas

Developmental Biology
Pediatrics, Perinatology, and Child Health

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Prediction of respiratory distress syndrome by the level of pulmonary surfactant protein A in cord blood sera. / Cho, Kazutoshi; Matsuda, Tadashi; Okajima, Satoru; Matsumoto, Yoshinori; Sagawa, Tadashi; Fujimoto, Seiichiro; Kobayashi, Kunihiko.

In: Biology of the Neonate, Vol. 77, No. 2, 01.02.2000, p. 83-87.

Research output: Contribution to journal › Article › peer-review

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abstract = "The purpose of this study was to determine the utility of measuring the level of pulmonary surfactant protein A (SP-A) in cord blood sera to predict for respiratory distress syndrome (RDS). SP-A levels in cord blood sera from 48 infants born at gestational ages < 32 weeks were measured by a sandwich ELISA system. Mean value of SP-A in cord blood was 5.8 ng/ml in cases with RDS and 15.1 ng/ml in those without RDS (p = 0.002). The best cut-off point of cord blood SP-A to predict RDS was determined as 10 ng/ml. The sensitivity and the specificity of the cut-off point for predicting RDS were 81 and 76%, respectively. Multivariate regression analysis showed that high SP-A level in cord blood, premature rupture of the membranes longer than 24 h and heavy birth weight were all significantly related to the non-RDS outcome. Copyright (C) 2000 S. Karger AG, Basel.",

keywords = "Cord blood sera, Diagnosis, Lung maturation, Prediction, Premature infant, Pulmonary surfactant protein A, Respiratory distress syndrome",

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AU - Sagawa, Tadashi

AU - Fujimoto, Seiichiro

AU - Kobayashi, Kunihiko

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AB - The purpose of this study was to determine the utility of measuring the level of pulmonary surfactant protein A (SP-A) in cord blood sera to predict for respiratory distress syndrome (RDS). SP-A levels in cord blood sera from 48 infants born at gestational ages < 32 weeks were measured by a sandwich ELISA system. Mean value of SP-A in cord blood was 5.8 ng/ml in cases with RDS and 15.1 ng/ml in those without RDS (p = 0.002). The best cut-off point of cord blood SP-A to predict RDS was determined as 10 ng/ml. The sensitivity and the specificity of the cut-off point for predicting RDS were 81 and 76%, respectively. Multivariate regression analysis showed that high SP-A level in cord blood, premature rupture of the membranes longer than 24 h and heavy birth weight were all significantly related to the non-RDS outcome. Copyright (C) 2000 S. Karger AG, Basel.

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