Abstract
The purpose of this study was to determine the utility of measuring the level of pulmonary surfactant protein A (SP-A) in cord blood sera to predict for respiratory distress syndrome (RDS). SP-A levels in cord blood sera from 48 infants born at gestational ages < 32 weeks were measured by a sandwich ELISA system. Mean value of SP-A in cord blood was 5.8 ng/ml in cases with RDS and 15.1 ng/ml in those without RDS (p = 0.002). The best cut-off point of cord blood SP-A to predict RDS was determined as 10 ng/ml. The sensitivity and the specificity of the cut-off point for predicting RDS were 81 and 76%, respectively. Multivariate regression analysis showed that high SP-A level in cord blood, premature rupture of the membranes longer than 24 h and heavy birth weight were all significantly related to the non-RDS outcome. Copyright (C) 2000 S. Karger AG, Basel.
Original language | English |
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Pages (from-to) | 83-87 |
Number of pages | 5 |
Journal | Biology of the Neonate |
Volume | 77 |
Issue number | 2 |
Publication status | Published - 2000 Feb 1 |
Keywords
- Cord blood sera
- Diagnosis
- Lung maturation
- Prediction
- Premature infant
- Pulmonary surfactant protein A
- Respiratory distress syndrome
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health