Prediction of respiratory distress syndrome by the level of pulmonary surfactant protein A in cord blood sera

Kazutoshi Cho, Tadashi Matsuda, Satoru Okajima, Yoshinori Matsumoto, Tadashi Sagawa, Seiichiro Fujimoto, Kunihiko Kobayashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The purpose of this study was to determine the utility of measuring the level of pulmonary surfactant protein A (SP-A) in cord blood sera to predict for respiratory distress syndrome (RDS). SP-A levels in cord blood sera from 48 infants born at gestational ages < 32 weeks were measured by a sandwich ELISA system. Mean value of SP-A in cord blood was 5.8 ng/ml in cases with RDS and 15.1 ng/ml in those without RDS (p = 0.002). The best cut-off point of cord blood SP-A to predict RDS was determined as 10 ng/ml. The sensitivity and the specificity of the cut-off point for predicting RDS were 81 and 76%, respectively. Multivariate regression analysis showed that high SP-A level in cord blood, premature rupture of the membranes longer than 24 h and heavy birth weight were all significantly related to the non-RDS outcome. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalBiology of the Neonate
Volume77
Issue number2
Publication statusPublished - 2000 Feb 1

Keywords

  • Cord blood sera
  • Diagnosis
  • Lung maturation
  • Prediction
  • Premature infant
  • Pulmonary surfactant protein A
  • Respiratory distress syndrome

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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