TY - JOUR
T1 - Prediction of pregnancy in infertile women with endometriosis
AU - Murakami, Takashi
AU - Okamura, Chikako
AU - Matsuzaki, Sachiko
AU - Terada, Yukihiro
AU - Yokomizo, Rei
AU - Noda, Takahiro
AU - Yaegashi, Nobuo
AU - Okamura, Kunihiro
PY - 2002
Y1 - 2002
N2 - To estimate the probability of pregnancy in infertile women with endometriosis, two series of multivariate analyses were performed in Tohoku University Hospital. In the first series, from 1993 to 1997, 103 patients participated. The Cox proportional hazard regression model revealed a hazard ratio of 2.43 in patients with high ovarian adhesion scores. Bilateral ovarian adhesion was an important variable in anatomical factors, probably second only to bilateral tubal adhesion. In the next series, from 1998 to 1999, 23 patients were included, and the preoperative serum concentrations of cytokines, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α were analyzed. Only TNF-α was selected with a forward stepwise analysis after forcing age and infertile duration. In the logistic regression model, the serum TNF-α level had a significant and negative impact on the likelihood of pregnancy.
AB - To estimate the probability of pregnancy in infertile women with endometriosis, two series of multivariate analyses were performed in Tohoku University Hospital. In the first series, from 1993 to 1997, 103 patients participated. The Cox proportional hazard regression model revealed a hazard ratio of 2.43 in patients with high ovarian adhesion scores. Bilateral ovarian adhesion was an important variable in anatomical factors, probably second only to bilateral tubal adhesion. In the next series, from 1998 to 1999, 23 patients were included, and the preoperative serum concentrations of cytokines, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α were analyzed. Only TNF-α was selected with a forward stepwise analysis after forcing age and infertile duration. In the logistic regression model, the serum TNF-α level had a significant and negative impact on the likelihood of pregnancy.
KW - Cytokines
KW - Endometriosis
KW - Infertility
KW - Multivariate analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=0036170333&partnerID=8YFLogxK
U2 - 10.1159/000049421
DO - 10.1159/000049421
M3 - Article
C2 - 11834865
AN - SCOPUS:0036170333
VL - 53
SP - 26
EP - 32
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
SN - 0378-7346
IS - SUPPL. 1
ER -