Prediction of pregnancy in infertile women with endometriosis

Takashi Murakami, Chikako Okamura, Sachiko Matsuzaki, Yukihiro Terada, Rei Yokomizo, Takahiro Noda, Nobuo Yaegashi, Kunihiro Okamura

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


To estimate the probability of pregnancy in infertile women with endometriosis, two series of multivariate analyses were performed in Tohoku University Hospital. In the first series, from 1993 to 1997, 103 patients participated. The Cox proportional hazard regression model revealed a hazard ratio of 2.43 in patients with high ovarian adhesion scores. Bilateral ovarian adhesion was an important variable in anatomical factors, probably second only to bilateral tubal adhesion. In the next series, from 1998 to 1999, 23 patients were included, and the preoperative serum concentrations of cytokines, interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α were analyzed. Only TNF-α was selected with a forward stepwise analysis after forcing age and infertile duration. In the logistic regression model, the serum TNF-α level had a significant and negative impact on the likelihood of pregnancy.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalGynecologic and Obstetric Investigation
Issue numberSUPPL. 1
Publication statusPublished - 2002


  • Cytokines
  • Endometriosis
  • Infertility
  • Multivariate analysis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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