Prediction of disordered regions in proteins based on the meta approach

Takashi Ishida, Kengo Kinoshita

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

Motivation: Intrinsically disordered regions in proteins have no unique stable structures without their partner molecules, thus these regions sometimes prevent high-quality structure determination. Furthermore, proteins with disordered regions are often involved in important biological processes, and the disordered regions are considered to play important roles in molecular interactions. Therefore, identifying disordered regions is important to obtain high-resolution structural information and to understand the functional aspects of these proteins. Results: We developed a new prediction method for disordered regions inproteins based on the meta approach and implemented a web-server for this prediction method named 'metaPrDOS'. The method predicts the disorder tendency of each residue using support vector machines from the prediction results of the seven independent predictors. Evaluation of the meta approach was performed using the CASP7 prediction targets to avoid an overestimation due to the inclusion of proteins used in the training set of some component predictors. As a result, the meta approach achieved higher prediction accuracy than all methods participating in CASP7.

Original languageEnglish
Pages (from-to)1344-1348
Number of pages5
JournalBioinformatics
Volume24
Issue number11
DOIs
Publication statusPublished - 2008 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Fingerprint Dive into the research topics of 'Prediction of disordered regions in proteins based on the meta approach'. Together they form a unique fingerprint.

  • Cite this