TY - JOUR
T1 - Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography
AU - Ishiwata, Kiichi
AU - Tsukada, Hideo
AU - Kubota, Kazuo
AU - Nariai, Tadashi
AU - Harada, Norihiro
AU - Kawamura, Kazunori
AU - Kimura, Yuichi
AU - Oda, Keiichi
AU - Iwata, Ren
AU - Ishii, Kenji
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research (C) No. 13470177 of Japan Society for the Promotion of Science (to R.I.) and for Research and Development of Technology for Measuring Vital Function Merged with Optical Technology, Research and Development Project Aimed at Economic Revitalization (to H.T.) and Budget for Nuclear Research of the Ministry of Education, Culture, Sports, Science and Technology (to K.K.). The authors thank Ms. Miyoko Ando for her care of the subject in PET measurement.
PY - 2005/4
Y1 - 2005/4
N2 - We performed preclinical and clinical studies of O-[11C]methyl- l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.
AB - We performed preclinical and clinical studies of O-[11C]methyl- l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.
KW - O-[C]methyl-l-tyrosine
KW - Positron emission tomography
KW - Tumor imaging
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U2 - 10.1016/j.nucmedbio.2004.11.005
DO - 10.1016/j.nucmedbio.2004.11.005
M3 - Article
C2 - 15820760
AN - SCOPUS:20144386658
VL - 32
SP - 253
EP - 262
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 3
ER -
