Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography

Kiichi Ishiwata; Hideo Tsukada; Kazuo Kubota; Tadashi Nariai; Norihiro Harada; Kazunori Kawamura; Yuichi Kimura; Keiichi Oda; Ren Iwata; Kenji Ishii

doi:10.1016/j.nucmedbio.2004.11.005

Preclinical and clinical evaluation of O-[¹¹C]methyl-L-tyrosine for tumor imaging by positron emission tomography

Kiichi Ishiwata, Hideo Tsukada, Kazuo Kubota, Tadashi Nariai, Norihiro Harada, Kazunori Kawamura, Yuichi Kimura, Keiichi Oda, Ren Iwata, Kenji Ishii

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

We performed preclinical and clinical studies of O-[¹¹C]methyl- l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[¹¹C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[¹¹C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[¹¹C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.

Original language	English
Pages (from-to)	253-262
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.nucmedbio.2004.11.005
Publication status	Published - 2005 Apr

Keywords

O-[C]methyl-l-tyrosine
Positron emission tomography
Tumor imaging

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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Preclinical and clinical evaluation of O-[¹¹C]methyl-L-tyrosine for tumor imaging by positron emission tomography. / Ishiwata, Kiichi; Tsukada, Hideo; Kubota, Kazuo; Nariai, Tadashi; Harada, Norihiro; Kawamura, Kazunori; Kimura, Yuichi; Oda, Keiichi; Iwata, Ren; Ishii, Kenji.

In: Nuclear Medicine and Biology, Vol. 32, No. 3, 04.2005, p. 253-262.

Research output: Contribution to journal › Article

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AU - Harada, Norihiro

AU - Kawamura, Kazunori

AU - Kimura, Yuichi

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AU - Iwata, Ren

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