Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography

Kiichi Ishiwata, Hideo Tsukada, Kazuo Kubota, Tadashi Nariai, Norihiro Harada, Kazunori Kawamura, Yuichi Kimura, Keiichi Oda, Ren Iwata, Kenji Ishii

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We performed preclinical and clinical studies of O-[11C]methyl- l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalNuclear Medicine and Biology
Volume32
Issue number3
DOIs
Publication statusPublished - 2005 Apr
Externally publishedYes

Keywords

  • O-[C]methyl-l-tyrosine
  • Positron emission tomography
  • Tumor imaging

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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