Practical study of immunotherapy in patients with Japanese cedar pollinosis using a questionnaire. comparison between sublingual immunotherapy and subcutaneous immunotherapy in the third season

Naoya Noguchi, Nobuo Ohta, Atsushi Yuta, Ph D.Yukiko Ogawa, Yusuke Kusano, Fumi Shoji, Shiori Kitaya, Naohiro Suzuki, Chikashi Kusakari, Kunitsugu Tabata, Eikan Kaku, Naohiro Okitsu, Jun Hasegawa, Yoshihiro Shibahara, Seiichiro Nakabayashi, Naoki Inamura, Yoshiyuki Ohi, Yoshitaka Takanashi, Jun Suzuki, Mitsuru SugawaraKazuhiro Nomura, Yukio Katori, Yoshitaka Okamoto

Research output: Contribution to journalArticlepeer-review

Abstract

Allergen immunotherapy has been shown to be effective in patients with allergic rhinitis AR and, unlike antiallergic drugs, has been shown to modify the underlying cause of the disease, with proved long term benefits. Subcutaneous immunotherapy SCIT is the gold standard, whereas sublingual immunotherapy SLIT has been developed more recently as an effective and safe alternative treatment modality. However, no studies have been carried out to compare the efficacy of SLIT and SCIT in patients with Japanese cedar pollinosis. Patients with Japanese cedar pollinosis who received SLIT and SCIT from 2014 to 2017 were enrolled the in present study. The clinical usage level, satisfaction level, and adverse effects of this treatment were investigated using a questionnaire survey between in the SLIT and the SCIT groups. The adherence, that is, clinical usage level was more than 70 % in both groups, which was within acceptable limits. The subjective symptoms improved and the patients were satisfied with this treatment in both groups. Of the total of 157 patients, 6 3.87% developed adverse effects with those involving the oral cavity and throat being the most common. All the adverse effects were minor, and none necessitated treatment discontinuation. The incidence of side effects was not higher in the SLIT group than in the SCIT group 3.17 % and 6.9 % respectively . These results led us to conclude that SLIT is an effective treatment alternative modality to SCIT in patients with Japanese cedar pollinosis.

Original languageEnglish
Pages (from-to)748-755
Number of pages8
JournalJournal of Otolaryngology of Japan
Volume124
Issue number5
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Japanese cedar pollinosis
  • Subcutaneous immunotherapy
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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