PPAR could contribute to the pathogenesis of hepatocellular carcinoma

Osamu Kimura, Yasuteru Kondo, Tooru Shimosegawa

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Viral hepatitis with hepatitis C virus or hepatitis B virus and chronic liver disease such as alcoholic or nonalcoholic steatohepatitis are critical factors in the development of hepatocellular carcinoma (HCC). Furthermore, diabetes is known as an independent risk factor for HCC. Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known. PPARs could contribute to the mechanisms of cell cycling, anti-inflammatory responses, and apoptosis. Therefore, to clarify the pathogenesis of HCC, we should examine PPAR signaling. In this paper, we have summarized the relevance of PPARs to the pathogenesis of HCC and cancer stem cells and possible therapeutic options through modifying PPAR signaling.

Original languageEnglish
Article number574180
JournalPPAR Research
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology (medical)

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