Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plant Vitis coignetiae (Vitaceae)

Y. Oshima, K. Namao, A. Kamijou, S. Matsuoka, M. Nakano, K. Terao, Y. Ohizumi

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

The methanol extract of the Oriental medicinal plant Vitis coignetiae (Vitaceae) showed hepatoprotective activity in the in vitro assay method using primary cultured rat hepatocytes. Activity-guided fractionation of the extract afforded e{open}-viniferin as an active principle. The protective effect of e{open}-viniferin against mice carbon tetrachloride-induced hepatic injury in mice was shown by serum enzyme assay as well as by pathological examination. In addition to e{open}-viniferin, plant oligostilbenes, ampelopsins A, C, F and the mixture of vitisin A and cis-vitisin A were also present in the extract. Among them, ampelopsin C and the mixture of vitisin A and cis-vitisin A were found to be powerful hepatotoxins.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalExperientia
Volume51
Issue number1
DOIs
Publication statusPublished - 1995 Jan 1

Keywords

  • Vitaceae
  • Vitis coignetiae
  • hepatoprotective substance
  • hepatotoxin
  • oligostilbene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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