Abstract
The concept of bifunctional asymmetric catalysis is very powerful for designing new enantioselective catalysts. We describe our investigation starting with the development of a BINOL-derived Lewis acid-Lewis base bifunctional asymmetric catalyst for cyanosilylation of aldehydes. The initial establishment of the concept was followed by the development of new sugar-derived catalysts that promote general catalytic enantioselective cyanosilylation of ketones. We also describe the catalytic enantioselective Reissert reaction of pyridine derivatives and Strecker reaction of ketoimines as recent advances in this field.
Original language | English |
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Pages (from-to) | 1491-1508 |
Number of pages | 18 |
Journal | Synlett |
Issue number | 10 |
DOIs | |
Publication status | Published - 2005 Jun 17 |
Externally published | Yes |
Keywords
- Asymmetric synthesis
- Catalysis
- Imines
- Lewis acids
- Pyridines
ASJC Scopus subject areas
- Organic Chemistry