Potentiation by febrifugine of host defense in mice against plasmodium berghei NK65

Kiyoshi Murata, Fumihide Takano, Shinji Fushiya, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The effect of febrifugine, the main alkaloidal constituent of an antimalarial crude drug, Dichroa febrifuga Lour., on protective immunity in mice infected with erythrocytic stage Plasmodium berghei NK65 was investigated. Febrifugine was administered orally, at a dose of 1 mg/kg/day, to mice before and/or after they were infected intraperitoneally with 2 x 106 parasitized red blood cells. Then, mortality and the levels of parasitemia and plasma NO3- [a degradation product of nitric oxide (NO)] were monitored. Febrifugine significantly reduced the mortality and the level of parasitemia. The plasma NO3- concentration began to rise within 2 days after treatment with febrifugine and declined to normal in 2 days when the mice were treated orally with febrifugine once a day for 3 consecutive days before parasite infection. This antimalarial activity of febrifugine was reduced by both N(G)-monomethyl-L-arginine and aminoguanidine. These results indicate that the increased production of NO by febrifugine plays an important role in host defense against malaria infection in mice. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1593-1601
Number of pages9
JournalBiochemical Pharmacology
Volume58
Issue number10
DOIs
Publication statusPublished - 1999 Nov 15

Keywords

  • Antimalarial activity
  • Febrifugine
  • Host defense
  • Malaria
  • Nitric oxide
  • Plasmodium berghei NK65

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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