Abstract
The mechanism(s) by which DNA vaccines trigger the activation of Ag-specific T cells is incompletely understood. A series of in vivo and in vitro experiments indicates plasmid transfection stimulates muscle cells to up-regulate expression of MHC class I and costimulatory molecules and to produce multiple cytokines and chemokines. Transfected muscle cells gain the ability to directly present Ag to CD8 T cells through an IFN-regulatory factor 3-dependent process. These findings suggest that transfected muscle cells at the site of DNA vaccination may contribute to the magnitude and/or duration of the immune response initiated by professional APCs.
Original language | English |
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Pages (from-to) | 329-336 |
Number of pages | 8 |
Journal | Journal of Immunology |
Volume | 179 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2007 Jul 1 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology