Potent Neurotoxins: Tetrodotoxin, Chiriquitoxin, and Zetekitoxin from Atelopus Frogs in Central America

Yong Hae Kim, Yun Bong Kim, Mari Yamashita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A mixture of the potent neurotoxins tetrodotoxin (TTX) and chiriquitoxin (CHTX) was isolated from the skins of the male and the eggs of the female frog Atelopus chiriquiensis from Costa Rica. Tetrodotoxin was also found in the skin of both populations of Atelopus varius varius and Atelopus varius ambulatorioux from Costa Rica. Zetekitoxin(ZTX) was isolated from Alelopus zeteki from Panama. The TTX, CHTX, and ZTX are potent neurotoxins and their toxicities are about the same (ca. 5-11 μg/Kg). The structural studies and biological activities of TTX, CHTX. and ZTX are described.

Original languageEnglish
Pages (from-to)521-532
Number of pages12
JournalJournal of Toxicology - Toxin Reviews
Volume22
Issue number4
DOIs
Publication statusPublished - 2003 Dec 22

Keywords

  • Atelopus frogs
  • Chiriquitoxin
  • Neurotoxin
  • Tetrodotoxin
  • Zetekitoxin

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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