Potent antioxidative activity of unripe fruits of Garcinia mangostana L.

Jue Feng, Tohru Yamakuni, Eishin Katoh, Shinya Hosoda, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The antioxidative activities of the EtOH extracts and the fractions of the extracts from the unripe fruits and ripe fruit hulls of Garcinia mangostana L., including H2O-soluble and H2O-insoluble fractions, were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical photometric assay. Among the tested samples, the EtOH extract and H2O-soluble fraction from the unripe fruits exhibited potent antioxidative activity with EC 50 values of 5.13 and 4.73 μg/ml, respectively. The farther purified fraction of the H2O-soluble fraction of the unripe fruits possessed the highest activity with an EC50 value of 3.60 μg/ml. The major antioxidative constituent in the H2O-soluble fraction of the unripe fruits was identified as (-)-epicatechin by the HPLC method, and the quantitative analyses showed that the (-)-epicatechin content in this fraction was approximately three times higher than that in the H2O-Soluble fraction from ripe fruit hulls, resulting in a potent antioxidative activity in the unripe fruits. These results suggest that the unripe fruits can be used as a prospective natural resource when searching for antioxidative agents.

Original languageEnglish
Pages (from-to)156-159
Number of pages4
JournalNatural Medicines
Issue number4
Publication statusPublished - 2004 Aug


  • (-)-epicatechin
  • Antioxidative activity
  • Garcinia mangostana
  • LC-MS analysis
  • Ripe fruit hull
  • Unripe fruit

ASJC Scopus subject areas

  • Molecular Medicine


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