Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters

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74 Citations (Scopus)

Abstract

Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

Original languageEnglish
Pages (from-to)3450-3452
Number of pages3
JournalAngewandte Chemie - International Edition
Volume52
Issue number12
DOIs
Publication statusPublished - 2013 Mar 18

Keywords

  • asymmetric reactions
  • one-pot reactions
  • organocatalysis
  • prostaglandins
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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