Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters

Yujiro Hayashi; Shigenobu Umemiya

doi:10.1002/anie.201209380

Pot economy in the synthesis of prostaglandin A₁ and E ₁ methyl esters

Yujiro Hayashi, Shigenobu Umemiya

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

Original language	English
Pages (from-to)	3450-3452
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	12
DOIs	https://doi.org/10.1002/anie.201209380
Publication status	Published - 2013 Mar 18

Keywords

asymmetric reactions
one-pot reactions
organocatalysis
prostaglandins
total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201209380

Cite this

@article{63bfa9e57f3b4eb4958bf30991532c2f,

title = "Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters",

abstract = "Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.",

keywords = "asymmetric reactions, one-pot reactions, organocatalysis, prostaglandins, total synthesis",

author = "Yujiro Hayashi and Shigenobu Umemiya",

year = "2013",

month = mar,

day = "18",

doi = "10.1002/anie.201209380",

language = "English",

volume = "52",

pages = "3450--3452",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "12",

}

TY - JOUR

T1 - Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters

AU - Hayashi, Yujiro

AU - Umemiya, Shigenobu

PY - 2013/3/18

Y1 - 2013/3/18

N2 - Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

AB - Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

KW - asymmetric reactions

KW - one-pot reactions

KW - organocatalysis

KW - prostaglandins

KW - total synthesis

UR - http://www.scopus.com/inward/record.url?scp=84875193245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875193245&partnerID=8YFLogxK

U2 - 10.1002/anie.201209380

DO - 10.1002/anie.201209380

M3 - Article

C2 - 23404945

AN - SCOPUS:84875193245

VL - 52

SP - 3450

EP - 3452

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 12

ER -