Pot economy in the synthesis of prostaglandin A1 and E 1 methyl esters

Yujiro Hayashi; Shigenobu Umemiya

doi:10.1002/anie.201209380

Pot economy in the synthesis of prostaglandin A₁ and E ₁ methyl esters

Yujiro Hayashi, Shigenobu Umemiya

SCI - Chemistry

Research output: Contribution to journal › Article

74 Citations (Scopus)

Abstract

Pot luck: Prostaglandins regulate a broad range of physiological processes and some of their derivatives are used as effective drugs, but previously their preparation has required many steps. The title compounds were efficiently synthesized in a small number of synthetic steps by using a recently developed organocatalyst and practical, one-pot operations involving several successive reactions.

Original language	English
Pages (from-to)	3450-3452
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	12
DOIs	https://doi.org/10.1002/anie.201209380
Publication status	Published - 2013 Mar 18

Keywords

asymmetric reactions
one-pot reactions
organocatalysis
prostaglandins
total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201209380

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Hayashi, Y., & Umemiya, S. (2013). Pot economy in the synthesis of prostaglandin A₁ and E ₁ methyl esters. Angewandte Chemie - International Edition, 52(12), 3450-3452. https://doi.org/10.1002/anie.201209380

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