Postmortem behaviour of rat microRNA (miRNA) as determined by comprehensive microarray analysis

Masaki Hashiyada, Kiyotaka Usui, Yoshie Hayashizaki, Jun Sakai, Masato Funayama

Research output: Contribution to journalArticlepeer-review

Abstract

We determined a number of miRNAs exist in rats after death using comprehensive microarray analysis with 350 rat miRNAs probes. Our analysis revealed that 237 miRNAs (67.7%) were under the threshold level and 105 (30%) were expressed until 48. h after death. Some miRNAs showed the unstable levels of expression at postmortem. Further investigations using quantitative PCR analysis and animal experiments are required before forensic application of this knowledge, such as estimation of time of death or quantification of stress.

Original languageEnglish
Pages (from-to)e210-e211
JournalForensic Science International: Genetics Supplement Series
Volume3
Issue number1
DOIs
Publication statusPublished - 2011 Dec

Keywords

  • MicroRNA (miRNA)
  • Microarray
  • Postmortem
  • Rat

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

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