Post-transplantation lymphoproliferative disorder in living-donor liver transplantation: A single-center experience

Chikashi Nakanishi, Naoki Kawagishi, Satoshi Sekiguchi, Yorihiro Akamatsu, Kazushige Sato, Shigehito Miyagi, Ikuo Takeda, Daizo Fukushima, Yoshinobu Kobayashi, Kazuyuki Ishida, Hidetaka Niizuma, Shigeru Tsuchiya, Motoshi Wada, Masaki Nio, Susumu Satomi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background Post-transplantation lymphoproliferative disorder (PTLD) is a group of life-threatening complications of organ transplantation, which occurs most frequently in pediatric patients. This retrospective study evaluates a single-institution experience of five cases of PTLD after living-donor liver transplantation (LDLT). Patients and method We reviewed the records of 78 pediatric patients (\18 years old) and 54 adult patients, who underwent LDLT between July 1991 and December 2009. Result PTLD was diagnosed in five pediatric patients, yielding an overall incidence of 3.8%. There were no significant differences between the pediatric patients with and those without PTLD in terms of their age, sex, reason for transplantation, calcineurin inhibitor, Epstein-Barr virus (EBV) serostatus, ABO compatibility, lymphocyte crossmatching, or episodes of biopsy proven rejection. Two patients with abdominal lymphadenopathy and one with gastrointestinal PTLD responded to a reduction in immunosuppression. Treatment with rituximab was necessary for another gastrointestinal PTLD patient. Diffuse large-B-cell lymphoma was diagnosed in one patient with mediastinal and lung masses. This patient was treated with chemotherapy and rituximab, followed by surgical resection. All patients survived and no evidence of recurrence has been found since. Conclusion Although PTLD is potentially life-threatening, it can be managed by appropriate and prompt treatment, with a good outcome.

Original languageEnglish
Pages (from-to)741-751
Number of pages11
JournalSurgery today
Volume42
Issue number8
DOIs
Publication statusPublished - 2012 Aug

Keywords

  • EBV
  • Liver transplantation
  • Living donor
  • PTLD
  • Rituximab

ASJC Scopus subject areas

  • Surgery

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